Biosynthetic rivalry of o-aminophenol-carboxylic acids initiates production of hemi-actinomycins in Streptomyces antibioticus
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چکیده
منابع مشابه
Incorporation of sarcosine into the actinomycins synthesized by Streptomyces antibioticus.
Sarcosine is an amino acid apparently not widely distributed in Nature. As a free amino acid, sarcosine has been demonstrated in the radial caeca of the starfish Astropecten aurantiacus (Kossel & Edlbacher, 1915), in the muscles of Elasmobranchii (Tarr, 1958) and in the reindeer moss, Cladonia itlvatica (Linko, Alfthan, Miettinen & Virtanen, 1953). Sarcosine has been found bound in peptides in ...
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The fine structure of the actinomycin producing bacterium Streptomyces antibioticus has been studied. The typical appearance of freshly ineculated cells is one of a generally electron dense cytoplasm. As cellular protein synthesis ceases and secondary metabolism (actinomycin biosynthesis) is initiated, a gradual loss of cytoplasmic density occurs, revealing in many cells membrane enclosed vesic...
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Using insertional mutagenesis, we have disrupted the RNase III gene, rnc, of the actinomycin-producing streptomycete, Streptomyces antibioticus. Disruption was verified by Southern blotting. The resulting strain grows more vigorously than its parent on actinomycin production medium but produces significantly lower levels of actinomycin. Complementation of the rnc disruption with the wild-type r...
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Actinomycin synthesis by washed mycelia of Streptomyces antibioticus has been conducted in the presence of 3-hydroxy-4-methylanthranilate-(carboxyl-(14)C). Incorporation of this compound into actinomycins has been observed, which constitutes further evidence that 3-hydroxy-4-methylanthranilate is an intermediate in actinomycin biosynthesis. The position of the incorporated label has been determ...
متن کاملA polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.
In the search for Type II polyketide synthases (PKSs) a DNA fragment was isolated from Streptomyces antibioticus ATCC 11891 (a producer of oleandomycin). DNA sequencing of the cloned fragment revealed six complete ORFs whose deduced products showed similarities to those of other genes known to be involved in polyketide biosynthesis. Several S. coelicolor strains mutated in different steps of ac...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2014
ISSN: 2046-2069
DOI: 10.1039/c3ra45661g